CDC estimates that in 2002, 1.7 million infections and 99,000 associated deaths occurred in United States hospitals; healthcare-associated infections (HAIs) have an estimated $33 billion in added healthcare costs and are among the top ten leading causes of death in the U.S.

In an effort to eliminate healthcare-associated infections, the Department of Health and Human Services has developed an action plan with five-year national prevention targets and metrics. The Colorado Department of Public Health and Environment (CDPHE) has received American Recovery and Reinvestment Act (ARRA) funding to help Colorado healthcare facilities work on specific prevention targets.

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